Advanced drug delivery systems that provide improved control over active ingredient release have become a focus for research. Aia Malik and Mark Cresswell, from Lucideon, explore the use of polymers and inorganic materials for advanced controlled release systems.
Organic polymers have had a significant impact on the market for the controlled delivery of therapeutic compounds, but recent developments in inorganic materials research have demonstrated great potential for their use as controlled drug delivery systems. Inorganic materials are providing improved alternatives to conventional controlled release formulations, while also providing solutions to unmet formulation challenges.
Active pharmaceutical ingredients (APIs) generally require inclusion within a drug delivery system consisting of various excipients and additives, such as preservatives or lubricants. A key component of the formulation is a controlled release agent, referred to as a controlled release technology (CRT), that can deliver sustained release. CRT is employed to enable a more efficacious delivery of the API, such that the rate of its release or absorption across biological membranes is improved, elimination is reduced or specific sites of action can be targeted.